Our Scientific Committee has been working relentlessly to secure an impressive lineup of outstanding speakers for RIWC24. As part of our Meet the Speaker series, we are delighted to introduce another esteemed speaker for our Retina International World Congress (RIWC24), Professor Frans Cremers.
Prof. Frans Cremers is a Professor of Ophthalmogenetics in the Department of Human Genetics at the Radboud University Nijmegen (Radboudumc). He is currently leading a Fighting Blindness and HRB joint-funded project exploring macular disease-associated genes and risk factors with a focus on the ABCA4-Stargardt disease.
Prof. Cremer’s team was significantly involved in the identification of thirty-two Inherited Retinal Diseases (IRD) – associated genes and you can learn more about his work in the bio below.
We are delighted to have Professor Cremers with us at the Retina International World Congress to present on the below:
Professor Frans Cremers bio:
Prof. Cremers is professor of ophthalmogenetics in the Department of Human Genetics in Nijmegen, The Netherlands. He performed his PhD study, entitled ‘positional cloning of the choroideremia gene’, in Nijmegen, under the supervision of Prof. B. Wieringa and Prof. H-H. Ropers. He headed the Division of Molecular Genetics from 1992 – 2011 and was the director of the master program Molecular Mechanisms of Disease from 2005 – 2010. He published 374 peer-reviewed papers and 15 book chapters, predominantly on molecular genetics of inherited retinal diseases (IRDs). He supervised 36 PhD students and 8 postdocs, of whom 7 are now full professors (among which Camiel Boon, Rob Collin, Anneke den Hollander, Ronald Roepman) or assistant professor (Susanne Roosing).
He initiated and coordinated national (RD5000) and international (European Retinal Disease Consortium) collaborations in the IRD field. He was the director of the Foundation Fighting Blindness USA Program Project Award entitled ‘Splice Modulation to Treat Inherited Retinal Diseases’.
His team was significantly involved in the identification of 32 IRD-associated genes, among which the X-linked choroideremia and RP3/RPGR gene, genes associated with Leber congenital amaurosis (CEP290, CRB1, LCA5), autosomal recessive retinitis pigmentosa (EYS, USH2A), autosomal recessive cone dystrophy (PDE6C, POC1B), as well as familial exudative vitreoretinopathy (TSPAN12, ZNF408). He also discovered the first hearing impairment gene, POU3F4, implicated in X-linked DFN3.
Recently, he published on the genomic and transcriptomic landscape of Stargardt disease type 1 (STGD1). He discovered hidden intronic mutations in the ABCA4 gene by sequencing >3.000 STGD probands and employing stem cell technology and transcriptomics.
Please click here to find the full CV of Prof. Cremers.